In Chapter 2, Shubin spends most of his time describing the
origin of our limbs and hands. He introduces viewpoints from well-known
surgeon, Sir Charles Bell (who believed that the anatomy of the hand was merely
perfect because of its complexity and it being ideally arranged for the way we
live) and anatomist, Sir Richard Owen (who believed that there were exceptional
similarities among creatures that were as different as frogs and humans). Owen found that there was some sort of
fundamental design among all vertebrate land animals and marine mammals. He specifically mentions lungfish and talks about how they have a single bone at the base of
the appendage, just like humans. Shubin talks more about the Tiktaalik fish and how it had a flat body, eyes that were
located on top of its head, and powerful limbs allowing them to maneuver more
easily through the water. They lived in an environment that consisted of very large predators. This strong musculature allowed for them to have the
ability to move to locations where predators could not reach/harm them. I think it’s
pretty intriguing how the Tiktaalik had this certain type of musculature (similar to
that of humans) because of the environment that they lived in. So far, I have
noticed that the book mentions many homologous relationships between humans and
fish and I remember that we went over this concept in class! Chapter 2 is about the structural homology of the fins and hands while chapter 3 touches on the particular gene in the hand (the ZPA gene) "that controls how they form and how they look like" (page 51). So once I finish reading chapter 3, I believe that I will be able to connect the dots by having background on both, the structural homologies introduced and the molecular homologies between humans and fish that will be talked about in the Handy Genes chapter. I like that the book
is allowing me to make these connections and I hope to make some more as I
continue reading.
Hey Ruby!
ReplyDeleteWhen you get to the part of the ZPA gene, think about the Hox genes and how they perform on a gradient of expression to create the axes orientations for proper development - I learned about these in Developmental Bio but Leah talks about this in her blog post, as well. Hox gene function and effects are a great parallel when thinking about the ZPA gene.
Hey Aparna! Yeah I noticed that Leah made that connection and I do remember learning about hox genes in both intro bio and microanatomy! I am almost done with chapter 3 and I am definitely being able to see the parallel between the two. Thanks Aparna!
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